In the past years, the processing of drugs was mostly achieved through wet granulation or related unit operations. Progressively, other methods emerged that revolutionalized and gradually replaced the old tablet manufacturing methods. Amongst the new techniques, the direct compression method uses the most advanced technology.
Manufacturing of tablets using direct compression method involves processes that can be condensed to three. The order following these processes first involves using induced die feeders, dry binders and lastly by using direct compression excipients.
In the process of using induced die feeders, a special feeding device is used. The device prevents segregation and complements the powders to flow down the die cavity of the pharmaceutical tablet compression machine from the hopper. Employing the induce die feeder usually minimizes entrapment of air thereby increasing the density of the filling powder and its susceptibility to compaction. Commonly used for a compact formulation that does not fill the die cavity.
In pharmaceuticals, the use of binders ensures that the active and inactive ingredients are held together. The substances used as dry binders must have the required cohesion properties so as to ensure that the tablets are of the approved hardness and crispiness. It is also recommended that a low binder to drug ratio should be maintained so as to ensure satisfactory sizes of the tablets that contain high doses of drugs. Microcrystalline cellulose and polyethylene glycol are some of the examples of dry binders that are commonly used to manufacture tablets using this technique.
Related: Tablet Manufacturing Process Flowchart
The manufacture of tablets by direct compression is advantageous as the whole process generally requires fewer steps in implementation without requiring the use of moisture and heat. Tablets made as a product of this method have faster dissolution properties as compared to those of wet granulation.
There may be a couple of reasons why direct compression is not suitable for all products. The main reason is that cases of high dosage may present a problem and low dosage may exhibit non-uniform blending.
In the process of using induced die feeders, a special feeding device is used. The device prevents segregation and complements the powders to flow down the die cavity of the pharmaceutical tablet compression machine from the hopper. Employing the induce die feeder usually minimizes entrapment of air thereby increasing the density of the filling powder and its susceptibility to compaction. Commonly used for a compact formulation that does not fill the die cavity.
In pharmaceuticals, the use of binders ensures that the active and inactive ingredients are held together. The substances used as dry binders must have the required cohesion properties so as to ensure that the tablets are of the approved hardness and crispiness. It is also recommended that a low binder to drug ratio should be maintained so as to ensure satisfactory sizes of the tablets that contain high doses of drugs. Microcrystalline cellulose and polyethylene glycol are some of the examples of dry binders that are commonly used to manufacture tablets using this technique.
Related: Tablet Manufacturing Process Flowchart
The manufacture of tablets by direct compression is advantageous as the whole process generally requires fewer steps in implementation without requiring the use of moisture and heat. Tablets made as a product of this method have faster dissolution properties as compared to those of wet granulation.
There may be a couple of reasons why direct compression is not suitable for all products. The main reason is that cases of high dosage may present a problem and low dosage may exhibit non-uniform blending.
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