A lot of pharma professionals have the confusion regarding the concept of water content (moisture content) and loss on drying. Both have a considerable difference to understand.
Water content is determined by the Karl Fischer titration method and it consists of only water i.e moisture content. The results do not contain other volatile matter except the water.
Loss on Drying is an unspecific analytical technique removing not only water but all other volatile impurities like alcohol etc. from a sample.
The degree of drying depends upon, 1) Temperature 2) Drying time
LOD or total moisture content analysis of Pharmaceutical products can include both bound (e.g. water of hydration) & free water.
In cases there are additional traces of other volatile impurities present, like alcohol; LOD may be higher than water content.
In other cases, LOD may be lower than water content, as bound crystal water may not be removed by heating.
% LOD = % Water content - % water molecule in the API
The Loss on Drying Test is designed to measure the amount of water and volatile matters in a sample when the sample is dried under specified conditions. e.g 105°C, 3 hours.
Water content is determined by the Karl Fischer titration method and it consists of only water i.e moisture content. The results do not contain other volatile matter except the water.
Loss on Drying is an unspecific analytical technique removing not only water but all other volatile impurities like alcohol etc. from a sample.The degree of drying depends upon, 1) Temperature 2) Drying time
LOD or total moisture content analysis of Pharmaceutical products can include both bound (e.g. water of hydration) & free water.
In cases there are additional traces of other volatile impurities present, like alcohol; LOD may be higher than water content.
In other cases, LOD may be lower than water content, as bound crystal water may not be removed by heating.
% LOD = % Water content - % water molecule in the API
The Loss on Drying Test is designed to measure the amount of water and volatile matters in a sample when the sample is dried under specified conditions. e.g 105°C, 3 hours.
nice differenciation
ReplyDeletenice differenciation
ReplyDeleteVery useful information, thanks for the initiation in guiding the people of pharma industry.
ReplyDeleteTq u very much sir
ReplyDeleteThere are innumerable things to know this One is great platform thanks alot
ReplyDeletewhat are the benfits to use the water content test instead of LOD and reason for changing the test from LOD to water content in finished product
ReplyDeleteNice
ReplyDeletethanks for this information, it's really useful
ReplyDeleteThnk u sir👍
ReplyDelete