Operation and Cleaning of Octagonal Blender : Pharmaguideline

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Operation and Cleaning of Octagonal Blender

Learn how to operate and clean the Octagonal Blender used in tablet manufacturing.

STARTUP

OPERATION

1. Check and ensure the cleanliness of the machine.
2. Bring the material near to the equipment to be blended.
3. Set the timer as per product specification mentioned in BMR. Load the material.
4. Switch ON the main push button and run the machine. Set RPM as per product specification mentioned in BMR.

SHUTDOWN

1. Switch OFF the main power supply.
2. Inform the maintenance people to switch OFF main power supply from electrical panel board on the service floor.

CLEANING (Days end cleaning)

1. Remove loosely stucked powder from the machine by using a vacuum cleaner, duster and a lint-free cloth.
2. Dismantle the machine in the following sequence and keep them on pallet-
A. Back lid
B. Charging lid
C. Single bolt baffle.
3. Clean the dismantled parts by using a vacuum cleaner, duster and a lint-free cloth.
4. Clean the machine and dismantle parts with a dry lint-free cloth.
5. Clean the room as per SOP No.
6. Assemble the cleaned dismantled parts.
7. After cleaning affix the cleaned equipment label on the equipment.
8. Record the cleaning details in the equipment log card.

CLEANING AT THE TIME OF BATCH CHANGEOVER / SAME PRODUCT OF ASCENDING POTENCY

1. Remove loosely stucked powder from the machine by using a vacuum cleaner, duster and a lint-free cloth.
2. Dismantle the machine in the following sequence and keep them on pallet-
A. Back lid
B. Charging lid
C. Single bolt baffle.
3. Clean the dismantled parts by using a vacuum cleaner, duster and a lint-free cloth.
4. Clean the machine and dismantle parts with a dry lint-free cloth.
5. Clean the room as per SOP No.
6. Assemble the cleaned dismantled parts.
7. After cleaning affix the cleaned equipment label on the equipment.
8. Record the cleaning details in the equipment log card.
Related: SOP for Product Changeover in Manufacturing

CLEANING AT THE TIME OF PRODUCT CHANGEOVER / SAME PRODUCT OF DESCENDING POTENCY / PREVENTIVE MAINTENANCE OF THE CONTACT PARTS

1. Remove loosely stucked powder from the machine by using vacuum cleaner, duster and lint free cloth.
2. Dismantle the machine in the following sequence and keep them on pallet-
A. Back lid
B. Charging lid
C. Single bolt baffle.
3. Clean the exterior of the machine vacuum cleaner and lint free cloth.
4. Wash the dismantled parts with running water followed by rinsing with purified water.
5. Wipe all parts with 2% NaOH solution using cotton duster and allow it to remain as such for 5 to 10 minutes.
6. Clean all above parts in running potable water using cotton duster.
7. Rinse all above parts with sufficient quantity of purified water.
8. Collect the final rinse in properly identified conical flask and send the same to Q.A. department.
9. Dry the dismantled parts using dryer.
10. Assemble the cleaned dismantled parts.
11. After cleaning, affix the cleaned equipment label on the equipment.
12. Record the cleaning details in the equipment log card.





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of pharmaguideline.com, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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