Preparation and Standardization of 0.1 M Zinc Chloride : Pharmaguideline
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  • Sep 25, 2010

    Preparation and Standardization of 0.1 M Zinc Chloride

    Preparation and standardisation of the 0.1 M Zinc Chloride using Disodium Edetate solution and Xylenol orange mixture as indicator used for pharmaceutical analysis.

    Zinc Chloride Solution Preparation

    • Add about 13.63 gm of granulated zinc (previously washed with 0.1M HCl and then water) and dissolve in a minimum amount of 2 M HCl.
    • Add more about 700 ml of purified water, mix and allow to cool to room temperature.
    • Make up the volume 1000 ml with purified water. Mix solution thoroughly.
    • Keep the solution for at least an hour and then carry out the standardization.

    Zinc Chloride Solution Standardization

    Method I

    • Take 25 ml of 0.1 M Zinc chloride solutions into a clean & dried conical flask.
    • Add about 4 gm ammonium acetate.
    • Add 25 ml distilled water and add about 50 mg xylenol orange mixture. shake well.
    • Add sufficient hexamine.
    • Titrate the above solution with standardized 0.1 M Disodium Edetate with constant stirring and until the solution gives a yellow color.
    • Note down the burette reading.
                                                              Molarity of EDTA x Burette Reading
    Molarity of 0.1 M Zinc chloride = -----------------------------------------------------
                                                                                      25

    Method II

    • To 25.0 ml of the solution add 4 g of ammonium acetate and 25 ml of water. 
    • Add 50 mg of xylenol orange mixture and sufficient hexamine, and titrate with 0.1 M disodium edentate until the colour changes to yellow.
    • 1 ml of 0.1 M disodium edetate is equivalent to 0.013630 g of ZnCl2.
    Also see: Determination of Shelf Life of Solutions in Laboratory

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