Method of Analysis for Sodium Hydroxide : Pharmaguideline

Online GMP Courses with Certificate

ENROLL

Method of Analysis for Sodium Hydroxide

Procedure for analysis for Sodium Hydroxide in pharmaceutical quality control laboratory.

1. Description

White, crystalline masses supplied as sticks, pellets or slabs; deliquescent.

2. Solubility

Very soluble in water; freely soluble in ethanol (95%).

3. Assay

Limit: NLT 97.0 % & NMT 100.5 %.
Reagent required
Phenolphthalein
Methyl orange
1M Hydrochloric acid
Procedure: Weigh accurately about 2 g, dissolve in about 80 ml of carbon dioxide-free water, add 0.3 ml of phenolphthalein solution and titrate with 1M hydrochloric acid. Add 0.3 ml of methyl orange solution and continue the titration with 1M hydrochloric acid. Each ml of 1M hydrochloric acid used in the second part of the titration is equivalent to 0.1060 g of Na2CO3. Each ml of 1M hydrochloric acid used in the combined titrations is equivalent to 0.0400 g of total alkali, calculated as NaOH.
Calculation
                                             Total B.R. X Molarity X 0.04X100
% of Sodium Hydroxide = ------------------------------------------
                                                    Wt. Taken in gm X 1.0





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of pharmaguideline.com, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question


3 comments: Post Yours! Read Comment Policy ▼

  1. What is total B.R

    ReplyDelete
  2. Anonymous19 April

    Caustic Lye %=f*br*normality/wt.

    Where
    f=factor= 4
    Br=burette reading of 0.1 N NaOH required to n for titration
    N= normality of 0.1N NaOH
    Wt= weight taken of caustic lye sample.

    ReplyDelete

Please don't spam. Comments having links would not be published.


Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration Warning Letters Education B.Pharmacy
Online Courses


Follow Pharmaguideline


DOCUMENTS

PHARMACEUTICAL DOCUMENTS




Editable Pharmaceutical Documents in MS-Word Format. Ready to use SOPs, Protocols, Master Plans, Manuals and more...

View


adsbypg


Recent Posts