SOP for Temperature Mapping Study : Pharmaguideline

Online GMP Courses with Certificate

ENROLL

SOP for Temperature Mapping Study

Standard operating procedure of temperature mapping study in biological incubators, refrigerator and freezer using calibrated probes and data logger in pharmaceutical industries.

1.0 OBJECTIVE

To lay down the procedure for temperature mapping.

2.0 SCOPE

This SOP shall be applicable for walk-in coolers, biological incubators, refrigerator and freezer.

3.0 RESPONSIBILITY

Officer/ Executive/ Assistant Manager

4.0 ACCOUNTABILITY

HOD of Engineering and QA

5.0 PROCEDURE

5.1 Temperature mapping is to be carried out by using the calibrated temperature probes and data logger.
5.2 Identify positions & number of locations for temperature mapping such that, it covers every corner & center of the chamber.
5.3 Prepare a protocol for temperature mapping indicating objective, scope, responsibilities, methodology, acceptance criteria, calibration status, summary and conclusion.
5.4 Protocol to be prepared by officer/ executive of concerned department, checked by the head of concerned department and shall be approved by head QA/QC.
5.5 Place temperature probes at the identified locations without touching the tip to any surface inside the chamber.
5.6 Select the number of channels and set the print interval of 30 minutes on the data logger.
5.7 Start the mapping after stabilization of the displayed temperature.
5.8 Record the temperature readings of each probe in temperature mapping record.
5.9 If results do not fall within the specified limit, take necessary corrective actions to rectify the failure & perform the mapping again.
5.10 Final report for temperature mapping to be prepared by officer/ executive of the concerned department based on results obtained indicating the summary and conclusion.
5.11 Report shall be checked by the head of concerned department and shall be approved by head QA/QC.
5.12 After approval of the report daily monitoring shall be done at the identified hot spot.
5.13 For new equipment, the mapping is to be done for three consecutive days.
5.14 Remapping to be done for equipment once in the year for 24 hours.

5.15 Acceptance Criteria

Temperature shown by individual temperature probe should not be more than 25±2°C.

6.0 ABBREVIATIONS

6.1 SOP: Standard Operating Procedure
6.2 QA: Quality Assurance
6.3 QC: Quality Control
Get ready to use editable documents in MS-Word FormatView List





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of pharmaguideline.com, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question


3 comments: Post Yours! Read Comment Policy ▼

  1. Is there a Guide that defines the frequency of Ra-mapping ?

    ReplyDelete
  2. Hi the BS EN 17141 provide the guide for frequency of re-mapping

    ReplyDelete

Please don't spam. Comments having links would not be published.


Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration Warning Letters Education B.Pharmacy
Online Courses


Follow Pharmaguideline


DOCUMENTS

PHARMACEUTICAL DOCUMENTS




Editable Pharmaceutical Documents in MS-Word Format. Ready to use SOPs, Protocols, Master Plans, Manuals and more...

View


adsbypg


Recent Posts