Plastics in packaging have proved to be useful for the ease with which they are formed, high quality and the freedom to design. For pharmaceutical products, they are primarily made of polymers one of them being polyethylene.
Polyethylene has a demerit in that it lacks clarity and it has a relatively high rate of permeation of essential odors, flavors and oxygen. Even with this disadvantage, polyethylene in all its variations offers the best protection to products at the lowest cost possible.
Polymers are generally susceptible to oxidation degradation especially during processing and subsequent exposure which makes it necessary for addition of a subsequent antioxidant. The mainly used antioxidants include butylated hydroxytoluene.
The amount and nature of the additives are determined by the nature of the polymer, which is usually used to convert the polymer into the container. The containers manufactured for pharmaceutical purposes must always be free of substances which can be extracted in qualities significant by the product contained which enable hazards of toxicity and chemical instability to be avoided at all cost.
The additives mostly added to bottle-grade polyethylene are antistatic additives which minimize airborne dust accumulation at the surface of the bottle during filling, storage and handling. The antistatic additives are usually polyethylene lung chain fatty amides which are usually used at 0.1% -0.2%. The additives may consist of antioxidants, lubricants, impact modifier, plasticizers, stabilizers, colors and antistatic agents.
The additives mostly added to bottle-grade polyethylene are antistatic additives which minimize airborne dust accumulation at the surface of the bottle during filling, storage and handling. The antistatic additives are usually polyethylene lung chain fatty amides which are usually used at 0.1% -0.2%. The additives may consist of antioxidants, lubricants, impact modifier, plasticizers, stabilizers, colors and antistatic agents.
The high-density polyethylene containers are extremely resistant to breakage which enables it to offer safety to consumers with a reduction of losses due to breakage during distribution and their use. Modification it is the physical and chemical properties of pharmaceutical packaging material in which permeation, sorption and leaching alter the properties of the plastic which may lead to degradation.
In case the quantity of the dispensed drug with one being more squeezed leads to a relaxation of hard pressure which permits the product being sucked into the tube. Containers for the pharmaceutical use made of polyethylene material are able to retain their shape throughout its use, it is leak proof, unbreakable and has a unique suck-back feature.
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