Preparation and standardisation of 0.0167 M Potassium Dichromate solution using Sodium Thiosulphate and Starch solution as indicator used for analysis of pharmaceutical ingredients.
Potassium Dichromate Solution Preparation
- Weigh 4.9 g of potassium dichromate, previously powdered and dried in a desiccator for 4 hours.
- Dissolve in sufficient water to produce 1000 ml. Standardize the solution in the following manner.
Potassium Dichromate Solution Standardization
- To 20.0 ml of the solution add 1 g of potassium iodide and 7 ml of 2 M hydrochloric acid.
- Add 250 ml of water and titrate with 0.1 M sodium thiosulphate, using 3 ml of starch solution, added towards the end point of the titration, as indicator until the color changes from blue to light green.
- 1 ml of 0.1 M sodium thiosulphate is equivalent to 0.0049 g of K2Cr2O7.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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